Rapid Access to Spirocyclized Indolenines via Palladium-Catalyzed Cascade Reactions of Tryptamine Derivatives and Propargyl Carbonate

Journal article

Thomas D. Montgomery, Antoinette E. Nibbs, Ye Zhu, V. Rawal
Organic Letters, 2014

Semantic Scholar DOI PubMedCentral PubMed

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APA Click to copy
Montgomery, T. D., Nibbs, A. E., Zhu, Y., & Rawal, V. (2014). Rapid Access to Spirocyclized Indolenines via Palladium-Catalyzed Cascade Reactions of Tryptamine Derivatives and Propargyl Carbonate. Organic Letters.

Chicago/Turabian Click to copy
Montgomery, Thomas D., Antoinette E. Nibbs, Ye Zhu, and V. Rawal. “Rapid Access to Spirocyclized Indolenines via Palladium-Catalyzed Cascade Reactions of Tryptamine Derivatives and Propargyl Carbonate.” Organic Letters (2014).

MLA Click to copy
Montgomery, Thomas D., et al. “Rapid Access to Spirocyclized Indolenines via Palladium-Catalyzed Cascade Reactions of Tryptamine Derivatives and Propargyl Carbonate.” Organic Letters, 2014.

BibTeX Click to copy

@article{thomas2014a,
  title = {Rapid Access to Spirocyclized Indolenines via Palladium-Catalyzed Cascade Reactions of Tryptamine Derivatives and Propargyl Carbonate},
  year = {2014},
  journal = {Organic Letters},
  author = {Montgomery, Thomas D. and Nibbs, Antoinette E. and Zhu, Ye and Rawal, V.}
}

Abstract

We report the intermolecular palladium-catalyzed reaction of tert-butyl propargyl carbonate with tryptamine derivatives or other indole-containing bis-nucleophiles. The reaction proceeds under mild conditions and with low catalyst loadings to afford novel spiroindolenine products in good to high yields.