Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles

Journal article

Thomas D. Montgomery, V. Rawal
Organic Letters, 2016

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APA Click to copy
Montgomery, T. D., & Rawal, V. (2016). Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles. Organic Letters.

Chicago/Turabian Click to copy
Montgomery, Thomas D., and V. Rawal. “Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles.” Organic Letters (2016).

MLA Click to copy
Montgomery, Thomas D., and V. Rawal. “Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles.” Organic Letters, 2016.

BibTeX Click to copy

@article{thomas2016a,
  title = {Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles},
  year = {2016},
  journal = {Organic Letters},
  author = {Montgomery, Thomas D. and Rawal, V.}
}

Abstract

We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control.